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11-deoxycortisol cortoxelone cortodoxone deoxyhydrocortisone glucocorticoid steroid hormone structure tetrahydro metabolism cyclic cytidine monophosphate dihydrouracil glucuronic acid methylumbelliferyl hydroxyprogesterone reichstein's substance 3d rendering chemical molecule molecular structural formula compound production drug preparation hormonal therapy replacement function action level prohormone steroidal synthetic metabolite biosynthesis mechanism biosynthetic precursor synthesis derivative bioprecursor metabolic