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3-keto-5alpha-abiraterone abiraterone acetate hsd17b4 backdoor pathway galeterone akr1c3 d4a androgen receptor pregnenolone testosterone inhibition cyp17a1 alpha reductase lapc4 adrenal lncap androgenic prostate cancer 3d rendering chemical molecule molecular structural structure formula hormone hormonal function action level male sex carcinogen carcinogenicity carcinogenic tumor promotion malignancy angiogenesis metabolite metabolism precursor synthesis