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7-dehydrodesmosterol dehydrodesmosterol cholesterol dehydrocholesterol reductase biosynthesis lipid synthesis kegg hmg coa zymosterol cholesta slos pathway sterols fatty acid sterol intermediate steroid substrate enzyme precursor desmosterol 3d rendering chemical molecule molecular structural structure formula hormone hormonal function action endocrine metabolite metabolism cycle mechanism path catabolism biosynthetic hmdb derivative bioprecursor metabolic