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androstanediol neurosteroid androgens dihydrotestosterone dht androstane positive allosteric modulator gabaa receptor anticonvulsant anxiolytic pro-sexual sex hormone-binding globulin shbg hormone hormonal function action endocrine level prohormone analogue steroid steroidal endogenous molecule molecular formula skeletal structural structure bioactive biochemistry metabolite metabolism biosynthesis mechanism biosynthetic intermediate biogenesis substrate precursor synthesis derivative bioprecursor metabolic enzyme contractor 3d