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bilirubin glucuronide metabolite reaction intermediate bilirubin conjugated di-glucuronide macrophages phagocytize hemoglobin red blood corpuscles rbcs cells blood plasma albumin glomerular filtration lipoprotein glucuronic acid pyrrole rings dubin–johnson syndrome excretion liver kidney hyperbilirubinemia rotor biliary duct blockage liver failure hepatitis gilbert’s neonate jaundice hemolytic hemolysis rendering metabolism cycle substrate hmdb biosynthesis metabolic polycyclic biosynthetic ring path catabolism bioprecursor heterocyclic precursor