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dihydroethisterone dhet he-3562 progestin progestogen androgen anabolic steroid ethynylandrostanolone active metabolite hormonal antineoplastic agent steroid hormone receptors 5a-reductase androgen receptor ar dihydrotestosterone synthesis rendering metabolism biosynthesis cycle mechanism pathway path catabolism biosynthetic intermediate biogenesis substrate precursor derivative bioprecursor metabolic enzyme endogenous contractor hormone hormonal therapy replacement function action endocrine level prohormone analogue human metabolome database hmdb