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flavanonol flavonoid flavonol flavone isoflavone glycoside chrysandroside gordonia chrysandra herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia metabolite metabolism biosynthesis cycle mechanism pathway path catabolism biosynthetic intermediate biogenesis substrate smilax glabra synthesis derivative bioprecursor metabolic enzyme endogenous molecule molecular formula skeletal structural structure paepalanthus argenteus biochemistry biomolecule bioactive biochemical 3d