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isorhamnetin o-methylated flavonol flavonoids 3-methylquercetin isorhamnetol isorhamnetine iso-rhamnetin 3-methoxyquercetin quercetin derivative food pigment spice herbal medicinal mexican tarragon tagetes lucida supercritical fluid extraction enzyme quercetin 3-o-methyltransferase s-adenosyl methionine rendering supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary antioxidant anti-cancer anti-aging healthy aging alternative medicine herbal phytochemical phytotherapy plant herb natural pharmacopoeia parasympathomimetic flavonoid phytoalexin phytoestrogen