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lipoic acid la alpha-lipoic ala thioctic organosulfur compound dithiooctanoic caprylic aerobic metabolism supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary cofactor vitamin enantiomer cellular transport fatty acid biosynthesis metabolite cycle mechanism pathway path catabolism biosynthetic intermediate biogenesis substrate precursor synthesis derivative bioprecursor metabolic endogenous contractor molecule molecular formula skeletal structural structure 3d