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pinosylvin organic compound trans-stilbene phenyl stilbenediol dihydroxystilbene fungal infection plant ozone stress fungitoxin wood heartwood pinaceae gnetum cleistostachyum glucuronidation bioavailability biosynthesis enzyme cinnamic acid curcumin 3d supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary vitamin antioxidant anti-cancer anti-aging healthy aging alternative medicine herbal herbal phytochemical phytotherapy herb natural herbalism pharmacognosy pharmacopoeia molecule molecular formula