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stemmadenine indole alkaloid monoterpenoid terpenoid monoterpene terpene pre-aquammycin preakuammicine dehydrosecodine catharanthine tabersonine catharanthus roseus subincanadines aspidosperma subincanum tabernaemontana dichotoma herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia metabolite metabolism biosynthesis cycle mechanism pathway path biosynthetic intermediate biogenesis substrate precursor synthesis derivative bioprecursor metabolic endogenous molecule molecular formula skeletal structural structure 3d