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surfactin bacterial cyclic lipopeptide amphiphilic gram-positive endospore bacillus subtilis antibacterial antiviral antifungal anti-mycoplasma hemolytic micellar concentrations micelles nonribosomal peptide synthetase surfactin cation-carrier pore-forming detergent peptidoglycan lipopolysaccharide membrane viruses capsid toxicity 3d antibiotic bacteria flora resistance bacterial antimicrobial bactericide pathogen gram-negative antibiotic-resistant antibacterial agent infections microorganism strain surfactant cleansing hydrophilic hydrophobic synthetic zwitterionic surface tension micelle surfaces