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tetrahydrofuran thf oxolane epoxybutane 1-oxacyclopentane butylene oxide cyclotetramethylene oxide fraction furanidin tetra-methylene heterocyclic aromatic aromaticity macrocyclic heterocycle ring polar solvent catalytic hydrogenation furan polymerization elastomeric polyurethane polyvinyl chloride pvc varnishes aprotic dielectric constant organometallic organolithium grignard reagent desiccant solid acid catalyst lewis basicity substance compound component agent functional group precursor synthesis reaction production molecule molecular formula skeletal structural structure 3d