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Acute Megakaryoblastic Leukemia. Blast In Bone Marrow. Acute Megakaryoblastic Leukemia Is Life-Threatening Leukemia In Which Malignant Megakaryoblasts Proliferate Abnormally. An Irregular Cytoplasmic Border Is Noted And Projections Resembling Budding Atypical Platelets Are Present. Blast In Bone Marrow, Wright X1000.