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fat binding proteins apolipoprotein low density lipoprotein receptor alzheimer disease central nervous system genotype cardiovascular ldl hdl lipoprotein high-density low-density chylomicron plasma markers arteria artery atherosclerosis blocked blood thinner cardiac cardiology cholesterol circulation clogged coronary diet flow heart triglyceride hypercholesterolemia obesity occlusion overweight passive plaque pressure red blood cell sedentary stroke vascular vein vessel liver macrophages