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receptor enzyme signaling kinase ligand cell protein atp second messenger adaptor scaffold dimerization autophosphorylation phosphorylation activation tyrosine serine threonine intracellular extracellular internalization desensitization downregulation recycling endocytosis amplification effectors modulation response specificity selectivity affinity termination inhibition antagonism pathway transduction complex cascade transmembrane surface ligandbinding domain downstream cellular ligandreceptor animation linked adp membrane enzyme-linked receptors proteins activate pathways binding