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ketogenesis ketones liver metabolism fatty acids acetylcoa glucose ketosis betaoxidation ketogenic diet insulin glucagon hormones atp mitochondria oxidation substrates enzymes acetone hyperketonemia pathway ketone bodies gluconeogenesis lipids glycogen pyruvate lactate carbohydrates triglycerides energy citrate mevalonate state coenzymes catabolism anabolism oxaloacetate malate ketolysis acetoacetylcoa ketolactic acid precursor glycolysis transporters