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Little Desert Cottontail Rabbit. Of All The Desert-Dwelling Mammals, The Desert Cottontail Is Probably The One You Will See Most Frequently. Preyed Upon By Everything From Snakes To Coyotes To Owls, Most Cottontails Are Killed Within Their First Year. These Rabbits Have Few Defenses Other Than Good Eyesight, Good Hearing, And The Ability To Flee Quickly. They Compensate For Heavy Losses By Reproducing At A Prodigious Rate. Female Cottontails Can Breed At 3 Months Of Age And Have Multiple Litters In A Year. Young Stay At The Nest For Only About 2 Weeks Before Venturing Off. These Reinforcements Make For A Fairly Constant Supply Of Cottontails.