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pathology microscopic photomicrograph melanoma medical malignant histology microscopy science biopsy disease tumor tissue skin microscope dermatology laboratory research treatment test pigment cells oncology dermis pigmented analysis closeup patient neoplasm carcinoma medicine ulcer vesicular nuclei melanocytes view pigmentation atypical damage technology migrating biological sample histological variant screening sunburn bone skin features irregular shapes epidermis dermis display high ratio varied indicating transformation surrounding areas healthy providing contrast composition emphasizes abnormal cellular architecture typical highlighting invasive nature complexity pathology creative