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background medical cancer disease cell tumor dribbling bladder gland histology urinary biopsy prostate benign male reproductive system adenocarcinoma hyperplasia epithelial cells abnormal growths aggressive atypical enlarged focal area glandular pattern tissue gleason grading gleasons score high-risk infiltrating intermittency malignant neoplasm micrograph show microscopic view moderately differentiated nodular prostatic obstructive proliferation fibre muscular fibro nodule chips chips psa level tumor turp urethra