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cellular metabolism lipid adipose tissue white adipocytes brown yellow fat triglycerides fatty acids esterification hydrolysis novo synthesis betaoxidation mitochondria peroxisomes carnitine palmitoyltransferase ii enzymes coenzyme acetyl coa citrate synthase acetylcholine adiponectin leptin glycerol3phosphate dehydrogenase hydroxymethylglutarylcoa hmgcoa reductase acid pathway insulin signaling energy storage obesity prevention